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Anti-BCL2 Monoclonal一抗

宿主 Mouse

英文名稱 Anti-BCL2 Monoclonal Antibody

別名 Bcl-2;PPP1R50;Apoptosis regulator Bcl 2;B cell leukemia/lymphoma 2

應用 WB IF

稀釋比例 WB 1:1000-2000. IF 1:100-200.

交叉反應 Human Mouse Rat

蛋白分子量 26kDa

Gene ID 596

保存 Store at -20°C. Avoid freeze / thaw cycles.

儲存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

純化方法 Affinity purification

亞型 IgG1

免疫原 A synthetic peptide coupled to KLH

性狀 液體

Public Immunogen Range A synthetic peptide coupled to KLH

Swiss Prot P10415

Subcellular Locations Endoplasmic reticulum membrane Mitochondrion outer membrane Nucleus membrane Single-pass membrane protein

克隆號 6B5

克隆類型 Monoclonal Antibody

背景資料 BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability.

參考文獻：

《Structural optimization and additional targets identification of antisense oligonucleotide G3139 encapsulated in a neutral cytidinyl-lipid combined with a cationic lipid in vitro and in vivo》 作者:Yuan Ma,Wenting Zhao,Yiding Li,Yufei Pan,Shuhe Wang,Yuejie Zhu,Lingxuan Kong,Zhu Guan,Jiancheng Wang,Lihe Zhang,Zhenjun Yang 期刊:Biomaterials 影響因子:10.273 PMID:30660994

Anti-BCL2 Monoclonal一抗